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The greatest complexity of the immune response is shown by vertebrates which are endowed with innate and acquired immunity. Immunological studies performed mostly in mammals have been the reference for studies in other vertebrates. The study of immunological fish defenses has advanced considerably in recent decades. This has been due to the key status of fish in terms of the evolution of acquired immunity and due to the rapid expansion of aquaculture over this period, wherein disease control is of prime concern. Most of the chapters not only review the current advances on fish immune defenses, but also show perspective for future research. The book will be of interest to scientists involved in fish immunology, fisheries and aquaculture as well as for students of fish biology. ... Read more

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Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.

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Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated. In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans. ... Read more

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1st, 1997, Humana Press. Thomas Jefferson University, PA. Comprehensive compendium of step-by-step techniques for gene expression. For investigators. Companion to: Recombinant Protein Protocols. Plastic-comb, spiral binding. 76 contributors, 51 U.S. ... Read more

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Neutrophils are autonomous cells, freely living within humans (and other mammals), which are responsible for combating infection by microbes. They are also responsible for causing damage to the host in inflammatory disease. Understanding how these cells interpret the environment and decide on an appropriate course of action is therefore vital for understanding both physiological and pathological inflammation. This report provides an overview of the intracellular signalling events within neutrophils which regulate their activity, including oxidase activation and "priming". ... Read more

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Intended for researchers in immunology, cell biology, virology and medicine, this book provides information on such topics as cytokine gene regulation, and animal models for acquired immunodeficiency syndrome. ... Read more

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In An Introduction to Immunology, the author includes the most recent information while emphasizing the basic fundamentals of each topic so that you obtain a broad outline of the subject.

The text elucidates fundamental concepts, such as the origin of the immune system, innate and acquired immunity, and cells and organs of the immune system. It discusses recent concepts and ideas regarding innate and acquired immunity, T-cell and B-cell activation and differentiation mechanisms, factors involved in rheumatoid arthritis, T-cell clonal anergy, NK cell receptors, strategies in production of new vaccines against pathogens, new information on the minor histocompatibility complex, and much more. Moreover, the author brings you up to date with the latest developments by reviewing recently proposed concepts on transplantation immunology, blocking of costimulatory signals, CTLA-4 mediated T-cell inhibition, immune tolerance, NK cell tolerance, HLA delivered peptides for immunosuppression, and tumor antigens coded by oncogens.

Covering subject matter based on the immunology course taught by the author for the past twenty years, Introduction to Immunology is an excellent text for graduate and postgraduate students, as well as a good reference book for teachers of biological sciences. ... Read more

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This volume is edited by Dr. Sudhir Gupta, internationally recognized expert in Immunology, Professor of Medicine, Pathology, Microbiology and Molecular Genetics. Topics include toll receptors, dendritic cells, NK cells, and complement receptors.

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This highly researched yeast, which represents a system used by cell biologists, geneticists and molecular biologists, has been given only minimal coverage in the literature. Its properties make it an excellent organism for DNA and related biotechnology reseach. This book, which is the first attempt to collate existing information in one source, will be an invaluable aid to those initiating projects with this organism. ... Read more

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Save hours of study time, build test taking confidence, and ace the USMLE Step 1 and course exams with most user-friendly, complete, and frequently updated review of medical microbiology and immunology available

There's no faster or more effective way to prepare for the USMLE Step 1 and course exams than Medical Microbiology & Immunology Examination. Completely updated throughout, the Ninth Edition offers a concise, high-yield review of the basic and clinical aspects of bacteriology, virology, mycology, parasitology, and immunology, with an emphasis on the clinical application of microbiology and immunology to infectious diseases.

Everything you need for fast and thorough exam preparation:

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This state-of-the-art reference provides timely and clinically and experimentally useful information on the major proteins of mast cell secretory granules that are released into the lung, skin, gut, eye, and other tissues under the influence of diverse stimuli;including cytokines, growth factors, neuropeptides, and allergen-bound immunoglobulin E.Demonstrates the important roles proteases play in the maintenance of tissue homeostasis as well as in the damaging events linked with allergy and other varieties of inflammation! ... Read more

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Mathematical biology is an interdisciplinary area that focuses on the application of mathematics to biology systems. Mathematical biology spans all levels of biological organization and biological function, from the configuration of biological macromolecules to the entire ecosphere over the course of evolutionary time. The International Conference on Mathematical Biology 2007 provides the opportunity to bring together the people, projects and issues from all over the world to share experiences and examine the challenge of applying mathematics to biological problems.

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This book introduces the students to immunological terms and concepts in everyday language and explains them fully. It aims to give students a thorough grounding in the concepts of both basic and clinical immunology. Provides information in the form of concise notes with the most important words and concepts being highlighted, making it easier to learn and understand. It has also taken into consideration the increasing class sizes by providing an accompanying software package of MCQ questions. Annotated lists of references and review articles are included. ... Read more

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The molecular structure of interleukin-2 (IL-2) and that of its receptor subunits provide a basis for understanding lymphocyte activation by IL-2 and the generation of effector cells capable of mediating cytotoxicity towards tumors. This book provides an up-to-date account of IL-2, its effect on lymphocyte function, and clinical applications. Internationally know experts review the molecular aspects of cell signalling, giving insight on the in vivo pathways of activation likely to be important in determining clinical responses.They also examine the use of cytokines, particularly IL-2, in the treatment of cancer, and describe the results of recent clinical trials using IL-2, as well as of adoptive cell therapy.Providing a clear account of recent progress, the book also reviews the problems involved in attempting to improve the therapeutic benefit of IL-2, along with the importance of mechanisms which subverse IL-2 responses.This is the most up-to-date account of molecular research and clinical trials in this area, and will be of great benefit to students and researchers in immunology, pharmacology, biochemistry, and oncology who are interested in this vitally important topic. ... Read more

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Based on the 1981 International Conference on Reproductive Immunology, this is a comprehensive survey of the rapidly-expanding field.The work of many distinguished contributors is presented in three parts: I. The Embryo as Antigen, II. The Placenta as Immunological Barrier, and III. Regulation of the Maternal Immune Response. ... Read more

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The latest volume in this series covers recent research in molecular biology and biochemistry.It provides information on such rapidly expanding areas as manipulatingmonoclonal antibodies, diseases of abnormal antigen receptor formation, and the molecular mechanisms of autoimmunity.It will be useful to researchers in molecular biology, immunology, and biochemistry who need to keep up with new developments in this field. ... Read more

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The aim of this book is to describe and discuss the preparation of immuno-gold probes, the progress and development of preparation methods suitable for immuno-electron microscopy, and the use of immuno-gold labeling at the microscopic level.The perspectives and limitations of the different methods used in combination with immuno-gold are evaluated not only in the methodology chapters, but also in the chapters where the validity of immuno-gold labeling is exemplified in a successful application to biological questions.In addition to examining cryosections as one of the most common preparation methods for immuno-electron microscopy, an alternative embedding method, such as freeze substitution of rapidly frozen samples, and replica methods, such as freeze-etching, fracture label, label fracture, and whole mount, are discussed in detail. This book is an excellent source for cell biologists, researchers, technicians, and students. ... Read more