Product Description
Recent advances in molecular genetics have provided new information facilitating identification of human subpopulations at increased risk for cancer development. This volume reviews the impact of both intrinsic genetic factors and extrinsic modifiers on human cancer risk. Emphasis is on susceptibility factors that are targets for chemical carcinogens, on intrinsic factors that modify cancer risk and on biomonitoring and extrinsic risk modification. ... Read more

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Univ. of Virginia, Charlottesville. Provides cutting-edge reviews of the etiology and treatment of the cancer and focuses on the molecular genetics of prostate cancer. Discusses a gene therapy approach for delivering novel therapeutic genes to target cells and review progress in developing a dendritic-cell based vaccine. DNLM: Prostatic Neoplasms--genetics ... Read more

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Colorectal cancer is a collective term for a heterogeneousgroup of diseases. In a large proportion of cases, the condition isattributable to genetic predisposition. Those directly involved in thetreatment of patients with cancer of the large bowel are confronted toan increasing degree with the genetic aspects of the disease. Infamilial and hereditary forms of the disorder periodic screening ofthe close relatives of the patients can in principle prevent diseaseand death from colorectal cancer. Presymptomatic diagnosis by means ofDNA technology is now possible in many cases of familial adenomatouspolyposis. Genetic diagnosis will be increasingly important for theidentification of high-risk groups.
This book summarizes those aspects of the genetics of colorectalcancer that are important for clinical pracice. It has been statedthat clinicians can contribute to the goal of reducing mortality fromcancer by asking each patient about his or her family history ofcancer. The aim of this book is to provide a guideline for themanagement of those situations in which the family history ofcolorectal cancer is found to be positive. ... Read more

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Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.

Key Features
The contents include:
* Clonal evolution of the metastasis phenotype
* Cell Cycle regulation
* Apoptosis in tumour growth and metastasis
* Angiogenesis in cancer
* Cell surface glycoproteins and their receptors
* Proteinases and their inhibitors in cancer invasion
* Oncogenes and cancer metastasis
* Developmental genes
* Tumour suppressor genes
* Metastasis suppressor genes
* Dominant metastasis-associated genes ... Read more

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This digital document is an article from Skin & Allergy News, published by International Medical News Group on March 1, 2003. The length of the article is 550 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Cowden syndrome more common than suspected. (Genetic Cancer Syndrome).
Author: Bruce Jancin
Publication: Skin & Allergy News (Magazine/Journal)
Date: March 1, 2003
Publisher: International Medical News Group
Volume: 34Issue: 3Page: 43(1)

Distributed by Thomson Gale ... Read more

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Leukemia is a malignant disease which continues to play acutting edge role in the discovery of new basic knowledge about themalignant process and about the potential for controlling thesemalignant diseases. Molecular Genetics and Therapy of Leukemia presentscontributions by leading investigators and scientific contributors tosuch topics as chromosome 16, chromosome 5, the BCL-2 gene, 11q23breakpoint leukemias, the p-53 suppressor gene and oncogene,hematopoietic stem cells, cytokines, detection of minimal residualdisease in acute lymphoblastic leukemia, autologous marrowtransplantation, the retinoblastoma gene, allogeneic bone marrowtransplant and chemotherapy of acute lymphoblastic leukemia. ... Read more

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This volume contains the majority of the invited keynote lectures presented by experts at the Third International Conference on Controversies in Tumor Prevention and Genetics on 12-14 February 2004 in St.Gallen, Switzerland. Together, they reveal the latest findings in oncogenetics and its relations to recent and future developments in primary and secondary tumor prevention, especially in breast, colon and lung cancer. All contributions are written and have been critically reviewed by internationally recognised leaders in the field.

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Designed to educate healthcare professionals, this CD-ROM covers the scientific concepts that explain the genetic basis for cancer, focusing on breast and colon cancer.It also provides a comprehensive account of issues in patient care such as risk assessment, genetic testing, and follow-up care.
The science part begins with a genetics refresher, followed by a section on malignant transformation that explains the series of mutations which accumulate to transform a normal somatic cell into a cancer cell.A subsequent section on hereditary and sporadic cancers compares and contrasts these two types, and another section shows how genes and the environment interact to increase the risk for cancer.Finally, breast cancer and colon cancer are presented as models for these concepts.
The patient care part opens with a tutorial on risk assessment. Then, in a section called "To Test or Not to Test," it explores genetic counseling for decisions about testing and gives detailed descriptions of the available tests. The "Managing Patients" segment describes the follow-up of people who are found to have BRCA1 or BRCA2 mutations.This deals with such issues as surveillance, prophylactic surgery, the use of HRT by women at high risk for breast cancer, and chemoprevention. ... Read more

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New York Univ., New York City. Explains that "bad genes" may contain an unexpected positive side. The carcinogenic effects of these metabolic genes can be potentially overcome or nullified. For researchers, clinicians, and students. ... Read more

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Cancer genetics is a quickly growing field within oncology. Theability to identify individuals at high risk for cancer improves thechance of early prevention and detection of cancer. The results ofgenetic testing affect quality of life, employment, and ability to beinsured. This volume will provide an overview of cancer genetics,inherited cancer susceptibility, and available services and testing,including both the risks and benefits of testing. Some of the topicscovered include: genetics of breast and ovarian cancer, testing minorsfor inherited cancer risk, chemoprevention of heritable cancer risk,genetics of colorectal cancer, insurance issues in genetic testing forcancer, ethical and legal issues in genetic testing for cancersusceptibility, testing for breast cancer risk in the Ashkenazim,estimating individualized risk of breast cancer, genetic counselingfor the individual with inherited cancer susceptibility, andcomponents of a genetic cancer risk clinic. While heritable cancersaccount for between five and ten percent of all cancer cases,molecular alterations attributable to specific inherited cancersusceptibility may give us important clues into the mechanism by whichcancer occurs, not only in predisposed individuals, but also forsporadic cases. ... Read more

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The past 20 years have seen a rapid increase in our understanding of the biology of cancer. And, advances in understanding the genetics of cancer are beginning to have an impact on the clinical management of malignant disease. Many of the genetic changes that underlie malignant transformation of cells and/or that distinguish malignant clones can be used as markers to diagnose, monitor, or characterize various forms of cancer. The purpose of this volume is to assess the current status of genetic testing in cancer management both from the standpoint of those tests and genetic markers that are presently available and from the perspective of genetic approaches to cancer testing that are likely to have an impact on cancer management in the near future. ... Read more

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The genetic epidemiology of rare, as well as common, tumors is investigated in this timely book. It offers advice on statistical and methodologic approaches to sound experimental design. Knowledge about computer models for data storage as well as for analysis is also provided. The strong clinical base of the book, together with the fresh approach to cancer etiology, presents a new slant for future research. The approach focuses attention on integrating genetics and epidemiology into the pursuit of cancer etiology. The topic is treated in depth, with representatives from several related disciplines. The book has a distinctively international flavor because of the scientific presentations from authorities working in Europe and the United States. ... Read more

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State Univ. of New York, Buffalo.Proceedings of the American Institute for Cancer Researcher's Seventh Annual Conference of the same name, held August 28-30, 1996, in Washington, D.C. DNLM: Neoplasms--etiology--congresses. ... Read more

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It has been recognized for almost 200 years that certainfamilies seem to inherit cancer. It is only in the past decade,however, that molecular genetics and epidemiology have combined todefine the role of inheritance in cancer more clearly, and to identifysome of the genes involved. The causative genes can be tracked throughcancer-prone families via genetic linkage and positional cloning.Several of the genes discovered have subsequently been proved to playcritical roles in normal growth and development. There are alsoimplications for the families themselves in terms of genetic testingwith its attendant dilemmas, if it is not clear that useful actionwill result. The chapters in The Genetics of Cancer illustrate what hasalready been achieved and take a critical look at the futuredirections of this research and its potential clinical applications. ... Read more